Edrophonium responsiveness not necessarily diagnostic of myasthenia gravis
Identifieur interne : 003076 ( Main/Exploration ); précédent : 003075; suivant : 003077Edrophonium responsiveness not necessarily diagnostic of myasthenia gravis
Auteurs : Shin J. Oh [États-Unis] ; Hyo K. Cho [États-Unis]Source :
- Muscle & Nerve [ 0148-639X ] ; 1990-03.
English descriptors
- Teeft :
- Acetylcholine, Acetylcholine receptor antibody, Arch neurol, Botulism, Clinical features, Cmap, Decremental response, Eaton lambert syndrome, Edrophonium, Edrophonium test, Electrophysiological improvement, Gravis, Lem, Muscle nerve, Muscle nerve march, Myasthenia, Myasthenia gravis, Myasthenic, Myasthenic syndrome, Neurol, Neurology, Overlap myasthenic syndrome, Positive edrophonium response, Positive edrophonium test, Receptor, Syndrome.
Abstract
Uneqivocally positive edrophonium tests, both clinically and electrophysiologically, were observed in a classic case of the Lambert–Eaton myasthenic syndrome. A review of the literature revealed that a positive edrophonium response has been reported in a majority of cases of myasthenia gravis (MG) and overlap myasthenic syndrome and in some cases of the Lambert–Eaton myasthenic syndrome, botulism, congenital myasthenic syndrome, drug‐induced myasthenic syndrome, the Guillain‐Barre syndrome, and amyotrophic lateral sclerosis. From this, we conclude that anunequivocally positive edrophonium test alone is not necessarily diagnostic of MG and that the diagnosis of MG should be based on the clinical features together with edrophonium‐responsiveness and other laboratory findings.
Url:
DOI: 10.1002/mus.880130302
Affiliations:
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Oh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Neurology, The University of Alabama at Birmingham, Veterans Administration Medical Center, Birmingham</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Cho, Hyo K" sort="Cho, Hyo K" uniqKey="Cho H" first="Hyo K." last="Cho">Hyo K. Cho</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Neurology, The University of Alabama at Birmingham, Veterans Administration Medical Center, Birmingham</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Muscle & Nerve</title><title level="j" type="alt">MUSCLE AND NERVE</title><idno type="ISSN">0148-639X</idno><idno type="eISSN">1097-4598</idno><imprint><biblScope unit="vol">13</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="187">187</biblScope><biblScope unit="page" to="191">191</biblScope><biblScope unit="page-count">5</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1990-03">1990-03</date></imprint><idno type="ISSN">0148-639X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0148-639X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetylcholine</term><term>Acetylcholine receptor antibody</term><term>Arch neurol</term><term>Botulism</term><term>Clinical features</term><term>Cmap</term><term>Decremental response</term><term>Eaton lambert syndrome</term><term>Edrophonium</term><term>Edrophonium test</term><term>Electrophysiological improvement</term><term>Gravis</term><term>Lem</term><term>Muscle nerve</term><term>Muscle nerve march</term><term>Myasthenia</term><term>Myasthenia gravis</term><term>Myasthenic</term><term>Myasthenic syndrome</term><term>Neurol</term><term>Neurology</term><term>Overlap myasthenic syndrome</term><term>Positive edrophonium response</term><term>Positive edrophonium test</term><term>Receptor</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Uneqivocally positive edrophonium tests, both clinically and electrophysiologically, were observed in a classic case of the Lambert–Eaton myasthenic syndrome. A review of the literature revealed that a positive edrophonium response has been reported in a majority of cases of myasthenia gravis (MG) and overlap myasthenic syndrome and in some cases of the Lambert–Eaton myasthenic syndrome, botulism, congenital myasthenic syndrome, drug‐induced myasthenic syndrome, the Guillain‐Barre syndrome, and amyotrophic lateral sclerosis. From this, we conclude that anunequivocally positive edrophonium test alone is not necessarily diagnostic of MG and that the diagnosis of MG should be based on the clinical features together with edrophonium‐responsiveness and other laboratory findings.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li></region></list><tree><country name="États-Unis"><region name="Alabama"><name sortKey="Oh, Shin J" sort="Oh, Shin J" uniqKey="Oh S" first="Shin J." last="Oh">Shin J. Oh</name></region><name sortKey="Cho, Hyo K" sort="Cho, Hyo K" uniqKey="Cho H" first="Hyo K." last="Cho">Hyo K. Cho</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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